Archives
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Based on cytological observations the existence of a mechani
2020-07-29
Based on cytological observations, the existence of a mechanism linking meiotic chromosome dynamics with cell-cycle progression has been inferred in C. elegans. Polarized nuclear organization is greatly extended in mutants that disrupt synapsis (Colaiácovo et al., 2003, MacQueen et al., 2002), hinti
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br Materials and methods br
2020-07-28
Materials and methods Results Discussion Enzymatically active DNA-PK is a central component of the cellular response to replication fork inhibition [6]. For instance, cdc42 inhibitor depleted of endogenous DNA-PKcs or expressing an enzymatically deficient kinase mutant are unable to effici
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olopatadine hcl mg DGKs are a family of
2020-07-28
DGKs are a family of enzymes which phosphorylate diacylglycerol (DAG) and convert it to phosphatidic olopatadine hcl mg (PA) [7]. DAG is an established activator of the conventional and novel protein kinase Cs, Ras guanyl nucleotide-releasing protein, Unc-13 and chimaerin [8], [9]. PA has also been
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59 7 br Funding JAN hold a predoctoral fellowship
2020-07-28
Funding JAN hold a predoctoral fellowship from Spanish Ministry of Economy and Competitiveness (MINECO), MTL is a Formación de Personal Investigador fellows and EA is a Formación de Profesorado Universitario fellow of the Spanish Ministry of Education. This work was supported in part by grants fr
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As consequence all of them were
2020-07-28
As consequence, all of them were efficiently characterized by the most important and crucial bonds with the biological target, as previously discussed for opioid receptor antagonist I, and therefore experienced the most favourable predicted binding affinity profiles, being in agreement with the exp
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The PCR product was expressed under T
2020-07-28
The PCR product was expressed under T7 promoter in E. coli, yielding transformants with 180-fold higher PPase activity than the host strain, clearly indicating that the open reading frame encodes a PPase. Like authentic B. subtilis PPase [22], the recombinant enzyme purified to homogeneity was activ
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In vertebrates PAH AhR CYP A
2020-07-28
In vertebrates, PAH-AhR-CYP1A axis has been well established. AhR-dependent transcriptional modulation is caused by the xenobiotic response TCS HDAC6 20b synthesis (XRE) located on its promoter sequences (Jeong and Kim, 2002). In few invertebrates, presence of AhR has been reported in arthropods, n
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Second we found a wide range of CMV DNA loads
2020-07-28
Second, we found a wide range of CMV DNA loads measured in BAL fluid specimens from patients with pneumonia in whom CMV causality was unlikely or reasonably ruled out attending to clinical (including therapeutic response to nonanti-CMV drugs), radiographic, lung autopsy histopathology or BAL fluid c
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Exon encodes a section of the extracellular
2020-07-28
Exon 3 encodes a section of the extracellular ligand-binding domain and two variants in the 5′ region were first identified in Drosophila melanogaster (Semenov and Pak, 1999). These variants were initially termed modules 1 and 2 and correspond to exons 3a and 3b, respectively. To date, exon 3 altern
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Serine phosphorylation is thought to be one of
2020-07-27
Serine 129 phosphorylation is thought to be one of the most important posttranslational modifications of αSyn. One of the principal observations in this study is that the phosphorylation (S129) of αSyn was observably potentiated in 6- and 9-month-old σ1R−/− mice. The level of phosphor-αSyn in dopami
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br Acknowledgment This work is supported by the German
2020-07-27
Acknowledgment This work is supported by the German Research Foundation (DFG) grant RA2717/2–1 (AYR and NF). The ubiquitin proteasome system The ubiquitin proteasome system (UPS) plays a significant role in the regulation of cell growth and survival, in addition to maintaining cellular homeos
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A strong support for a dual role
2020-07-27
A strong support for a dual role of microglia may be due to distinct microglial phenotypes, which have been broadly categorized into M1 (classically activated, pro-inflammatory) and M2 (alternatively activated, anti-inflammatory) (Martinez and Gordon, 2014, Franco and Fernandez-Suarez, 2015, Kawabor
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br CDKs as Direct Coactivators
2020-07-27
CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1. This is achieved at two levels because CDKs can affect gene expression by targeting global transcription
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br Materials and Methods br Results br
2020-07-27
Materials and Methods Results Discussion We first confirmed that translational repression of target mRNAs by vigilin (Figure 1). It is known that vigilin binds a large number of mRNAs (estimated 700 mRNAs; [12]). We demonstrate that vigilin directly interacts with the pyrimidine-rich elemen
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AR-13324 br Methods and materials br Results br Discussion
2020-07-27
Methods and materials Results Discussion The data reported herein establishes that the human CRF2(a) receptor is stringently regulated by a rapid and strong desensitization mechanism following activation by the urocortins or related stresscopin peptides but not CRF. Furthermore, UCN2 and UC