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br EBV Infection Epstein Barr
2019-10-18
EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T
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Tumor cells exposed to the effect of these compounds
2019-10-18
Tumor Estradiol Cypionate exposed to the effect of these compounds were shown to become chemo and radio-sensitive. Based on that, it was possible to anticipate the selectivity requirement for DNA-PK inhibition and the best route for their development. Accordingly, prompted by the clinical significa
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Homologous recombination HR has important roles
2019-10-18
Homologous recombination (HR) has important roles in the repair of stalled or collapsed DNA replication forks, as well as of DNA double-strand breaks. Among the factors required for HR in human phloridzin are RAD51, BRCA1, and BRCA2 (Davies et al., 2001, Sung and Klein, 2006, Xia et al., 2001). BRC
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br Results and discussion br Conclusion Analogues of
2019-10-18
Results and discussion Conclusion Analogues of 1,2,4-triazole and 1,3,4-oxadiazole have been designed, synthesized and characterized. To avoid late stage failure, it is important to study the preliminary pharmacokinetic parameters. The results of pharmacokinetic data suggested that, all molecu
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Of note BRQ and LFM are
2019-10-18
Of note, BRQ and LFM are two well-known immunosuppressive agents (Batt, 1999). As for LFM, it was reported as immunosuppressive therapy for bone marrow (Avery et al., 2004) and renal (Chon and Josephson, 2011) transplantation. Accumulating evidence indicated that organ transplant patients irrelevant
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hbv virus br Conclusion Blueberry is becoming
2019-10-18
Conclusion Blueberry is becoming a worldwide crop with the fastest rising consumer demand trends for its health benefits. However, the berry size is one of the key parameters for determining fruit quality and consumers’ preferences (Milic et al., 2018). Understanding the physiological and molecul
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Neuroinflammation is the one of the emerging causal factors
2019-10-18
Neuroinflammation is the one of the emerging causal factors contributing to these cognitive deficits. Therefore, we further tested the hypothesis that neuroinflammation is a key component contributing to the progression of spatial memory deficits during HH. Spatial memory deficits were observed afte
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br Role of ERK signaling in
2019-10-18
Role of ERK signaling in preventive and therapeutic potential of flavonoids in neurodegenerative diseases ERK is one of the main pharmacological targets of natural phenolic compounds and contributes to several therapeutic approaches including anti-atherogenic, anti-cancer, anti-colitis, anti-arth
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br Experimental section br Acknowledgments
2019-10-18
Experimental section Acknowledgments This work was supported by the National Natural Science Foundation of China (NSFC, Grant No. 81573285 and No. 81602965), the Natural Science Basic Research Plan in Shaanxi Province of China (Program No. 2018JM7071 and No. 2017JQ8002), and the Fundamental Re
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Introduction Glucose is the major carbon source in most orga
2019-10-18
Introduction Glucose is the major carbon source in most organisms. Cancer Ketoprofen clinical in particular require a steady source of energy to maintain growth and proliferation, and preferentially use glycolysis for their energy supply even under aerobic conditions. Glucose uptake in mammals is
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br No Evidence for Further ET Receptor Subtypes Further
2019-10-18
No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these
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It has been reported about
2019-10-17
It has been reported about the synthesis of benzyl bromide in our previous reports, as shown in , , The synthetic route of compounds – is depicted in , Briefly, the synthesis of pyrimidinedione derivatives was started from commercially available WAY-262611 . After alkylation of material with 1-b
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In the belief that DNA based nanosensors and DNA
2019-10-17
In the belief that DNA-based nanosensors and DNA microarrays should be easier to operate, faster, more accurate and more economically viable than PCR-based techniques, an electrochemical DNA biosensor was designed for detection of G. boninense[9], [10]. This was developed based on a gold electrode m
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br Materials and methods br
2019-10-17
Materials and methods Results Discussion To date, several reports have suggested an involvement of DGK in bipolar disorder. A splice variant at the COOH-terminus of DGKβ has been related to bipolar disorder [15] and DGKβ KO mice showed hyperactive behavior [17]. For the other DGK isoforms,
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br Acknowledgements br Introduction Serum triglyceride conce
2019-10-17
Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within appr