Archives
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Ubiquitination can occur on a single monoubiquitination or
2020-08-04
Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ
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The mechanism of protein degradation mediated by ubiquitin h
2020-08-04
The mechanism of protein degradation mediated by ubiquitin has been well studied; meanwhile, there are growing evidences that reveal the non-proteolytic roles of ubiquitin modification. Deubiquitination counteracts the ubiquitin cascade, including inhibiting E2 ubiquitin conjugating Nordihydroguaiar
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The analysis of the surface wettability by static contact
2020-08-04
The analysis of the surface wettability by static contact angle revealed a good grade of hydrophobicity of the non-irradiated nanocomposites, which are characterized by water contact angles (WCA) above 110° (Fig. 3). The WCA values strongly increase with the GNP-DNA content, reaching 134.9° ± 6.2° f
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Additionally the explosion of nanotechnology and the use of
2020-08-04
Additionally, the explosion of nanotechnology and the use of nanomaterials in DNA biosensors is further enhancing immobilization and interface capabilities of the DNA material with the electrode and, ultimately, the detection signal response [16], [17]. Metal nanoparticles are frequently added to co
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Nucleophosmin NPM which also plays a role on the nuclear
2020-08-03
Nucleophosmin (NPM1), which also plays a role on the nuclear export of ribosomal proteins and subunits (Maggi et al., 2008), is also a relevant MYC target, presumably through an interaction with CRM1. Conversely, it has been recently reported that specific SINE compounds reduce the levels of MYC in
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Mirtazapine Carbon dioxide is the gas most commonly applied
2020-08-03
Carbon dioxide is the gas most commonly applied for supercritical fluid extraction due to its low cost, high purity, safety and low critical properties. Since pure supercritical carbon dioxide (scCO2) is a lipophilic solvent, mixtures with organic solvents, especially alcohols, are used to increase
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Click chemistry is a kind of chemical synthesis to
2020-08-03
Click chemistry is a kind of chemical synthesis to acquire various molecular product through small units quickly assembling. It has been applied to natural polymers or synthetic origins in many different architectures including linear (e.g., PEG, polysaccharides, proteins), branched (e.g., dendrimer
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br Materials and methods br Results
2020-08-03
Materials and methods Results Discussion Neointimal VSMC accumulation contributes considerably to vessel occlusion observed in both autologous vein graft degeneration [1], [2] and in-stent restenosis [26], [27]. In this study, the potential for retarding VSMC proliferation and hence amelior
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L-NMMA citrate br Conclusion While previously the
2020-08-03
Conclusion While previously the C:P ratio of OA was thought to be an important determinant of plant P uptake from OA (e.g. Takeda et al., 2009) we found that this was not the case. Alternatively, the proportion of P in OA that was orthophosphate gave a reasonable indication of the availability of
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HOIP s ability to build linear Ub
2020-08-03
HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [4
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In humans several different small ubiquitin related modifier
2020-08-03
In humans, several different small ubiquitin-related modifier (SUMO) paralogs can be conjugated to cellular proteins. The human genome codes for five SUMO paralogs (SUMO1–5); of these, SUMO1 and the almost identical SUMO2 and SUMO3 are ubiquitously expressed. Sumoylation is executed by an enzymatic
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Through a molecular gain of
2020-08-03
Through a molecular gain-of-function approach, we demonstrated that Cx43 overexpression inhibits in vivo ES tumor growth, providing the first experimental evidence indicating that the decrease of Cx43 gene expression is one mechanism through which ES cells can acquire high tumor growth potential. Si
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As it was recently found native
2020-08-03
As it was recently found [28], native α-synuclein interacts with anion-binding groove between O and R (or P and Q) subunits of GAPDH which comprises NAD+-binding pocket and active site (Fig. 2A). In all 10 simulations, α-synuclein bound to this region of GAPDH (Fig. 2D, E). The following GAPDH resid
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Cigarette smoking plays a chief risk
2020-07-31
Cigarette smoking plays a chief risk factor in various neurovascular complications [21]. The mechanism of CSE induced neurovascular complications are activates the immune cells like glial cells, dendritic cells, mast cells and so on [22]. In addition, it also alters the cellular metabolic pathways l
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RING type dimers are generally formed in one of
2020-07-31
RING-type dimers are generally formed in one of two ways: 1) sequences outside the RING are primarily responsible for dimerization; or 2) the RING per se is responsible for dimerization. In both types, the two RINGs are positioned such that the E2 binding surfaces face away from each other (see Fig.