• In the present study we observed a decrease in

  2022-01-15

  

  In the present study, we observed a decrease in body weight gain in Tg rats. It is uncertain whether this effect is due to Denr, Gpr81, or Gpr109a. In this regard, Gpr81 mice have been reported to have reduced body weight gain [28]. Moreover, a small clinical study has reported that obese patients t

• br Materials and methods br Results

  2022-01-15

  

  Materials and methods Results Discussion In this study, the supF forward mutation assay showed that 5OHU induced mutations in human cells and that a C→T mutation was the predominant mutation among 5OHU-induced mutations. In addition, the DNA cleavage activity assay revealed that 5OHU was ex

• To confirm that these were bona fide

  2022-01-15

  

  To confirm that these were bona fide interactions, we investigated whether the potassium channel subunits or Tmem263 formed complexes with GLT-1 or DAT after immunoprecipitation. Lysates of HEK-293 cells previously cotransfected with HA-GLT-1 or HA-DAT, and either YFP-Kv7.3, YFP-Kv7.2 or YFP-Kv7.5 w

• br Materials and methods br Results br

  2022-01-15

  

  Materials and methods Results Discussion Our liver-specific Gck (−/−) mice and another line of liver-specific mice [13] exhibited impaired glucose tolerance. Furthermore, both knockout mice showed decreased hepatic glycogen content and reduced Pklr and Fas gene DRB in the liver [11]. Howev

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2022-01-15

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by Meleagrin mg deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30%

• br Competing interests br Acknowledgements

  2022-01-15

  

  Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when Saxagliptin synthesis is taken in orally as compared to infused intravenously [1]. Normally, t

• Primarily because secretase was a

  2022-01-15

  

  Primarily because γ-secretase was a therapeutic target in AD, a plethora of γ-secretase inhibitors (GSIs) have been developed that effectively inhibit γ-secretase cleavage in humans [16]. Indeed, “druggability” of γ-secretase has not been an issue even when the identity of the target was unknown in

• br Introduction The nature of chemotherapies is to

  2022-01-14

  

  Introduction The nature of chemotherapies is to relieve the tumor burden of the patients by eliminating cancer Clindamycin HCl via inducing cell death, mostly regulated cell death represented by apoptosis [1,2]. Dozens of anticancer agents including clinically used ones kill cancer cells by promo

• In conclusion the data reported in this study

  2022-01-14

  

  In conclusion, the data reported in this study have demonstrated an important role for FAAH substrates in the Lubiprostone receptor in the modulation of TLR4-induced neuroinflammatory and associated anhedonic responses, but not acute sickness behaviour. Such potent neuroimmunomodulatory effects were

• Most studies of HIF have

  2022-01-14

  

  Most studies of HIF-1α have focused on its transcriptional activity-dependent functions. However, our results indicate that the oxidative stress-related effects of mtHIF-1α occur independently of its translocation to the nucleus and do not require its transcriptional activity. In fact, several studi

• A series of P P ureas were explored

  2022-01-14

  

  A series of P3-P4 ureas were explored first and their anti-NS3 protease activity, antiviral properties in a HCV replicon cell-based assay and PK profiles examined. Installation of a methyl group on the P4 side nitrogen A-1210477 of the urea yielded , a molecule which retained intrinsic potency agai

• Several compounds have been described in the literature

  2022-01-14

  

  Several compounds have been described in the literature as inhibitors of the sGC. Among them, methylene blue and LY83583 () are not direct sGC inhibitors, but rather block cGMP formation by generating superoxide anion radicals that deactivate NO. Despite their extensive use in plethora of research s

• At days and hours after MI

  2022-01-14

  

  At 21 days and 24 hours after MI, the protein expressions of active JNK1 (P 10058-F4 of p38 was down-regulated only at 21 days after MI (P Discussion This study demonstrates the role of GSTP1 in HF by inhibiting the TRAF2-induced MAPK activation and the potent inhibitory effect of GSTP1 on TNF-α

• The experiments reported herein were designed to test

  2022-01-14

  

  The experiments reported herein were designed to test whether co-expression of MRP and GSTP1-1 offers a level of protection from certain cytotoxic drugs not achieved by the expression of either protein alone. This was accomplished by stable transfection with expression vectors into MCF7/WT cells, w

• Despite the association with asthma it

  2022-01-14

  

  Despite the association with asthma, it is not surprising that we did not find a relation between the percent predicted FEV1 and SNPs in GSNOR. FEV1 measured on a routine clinic visit is likely to be normal in most asthmatic children. FEV1 in children reflects a complex mix of factors in the growth

13777 records 382/919 page Previous Next First page 上5页 381382383384385 下5页 Last page