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The application of diuretics induce an increased rate of wat
2024-02-23
The application of diuretics induce an increased rate of water exiting brain cells encouraging the formation of increased intracellular polyphosphoric acid. In the absence of the diuretic water is retained in cells converting polyphosphoric XL184 to monophosphoric acid. The latter change decreases
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We next developed a system
2024-02-23
We next developed a system for staging severity. Our guiding principles were the following. Two types of information about the research participant are staged independently from each other: (1) grading disease severity using biomarkers and (2) grading the severity of cognitive impairment. Measures u
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br Preliminary remarks Expression of the transcription
2024-02-23
Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the BW 723C86 hydrochloride of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental fac
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At the last follow up nine
2024-02-23
At the last follow-up, nine patients had discontinued pyridostigmine within the first year postoperatively. Only one patient required pyridostigmine at a higher dose, but this was accompanied by successful weaning of prednisolone. None of the 5 patients who were on pyridostigmine treatment alone pri
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Osteocytes the most abundant cells in an adult skeleton are
2024-02-23
Osteocytes, the most abundant cells in an adult skeleton, are essentially mature osteoblasts that are surrounded by the products they secreted (Noble and Reeve, 2000). Osteocytes serve as mechanosensors that direct bone remodeling and that regulate the activities of osteoblasts and osteoclasts (Bone
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Further evidence for ACh GABA cotransmission had also been o
2024-02-23
Further evidence for ACh/GABA cotransmission had also been observed in the cortex. Extensive axonal arborization from cholinergic BF neurons exists throughout the cortical layers, allowing direct observation of cholinergic synaptic terminals. One study in the visual cortex of cat examined immunolabe
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However for a molecular target
2024-02-23
However, for a molecular target to be useful in AD, it must rescue behavioral as well as biochemical insults. In humans, AD memory impairments typically declare themselves initially as disruption of episodic memory and consolidation of new memories, eventually progressing to global cognitive decline
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br Acknowledgements DHA was funded
2024-02-23
Acknowledgements DHA was funded by a research grant from Viamet and IMB and DHA were/are consultants for Viamet/Innocrin. DHA also supported by NIH P51-OD011106. Introduction Congenital adrenal hyperplasia resulting from 17alpha-hydroxylase and 17,20-lyase deficiency (17OHD) is a rare autosom
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For these reasons the role played by autophagy in
2024-02-23
For these reasons, the role played by autophagy in environmental neurotoxicity is not always easily determinable. Indeed, although the neuroprotective role of autophagy has been shown by several studies, sometimes induction of autophagy was associate with deleterious effects (Glick et al., 2010, Sri
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br Concluding Remarks and Future Directions The physiologica
2024-02-23
Concluding Remarks and Future Directions The physiological significance of autophagy in neuronal function is steadily emerging. The studies discussed herein reveal that key neuronal functions, such as neurotransmitter release, pruning of dendritic spines, and behavioural outputs of neural network
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br Autophagy in cancer br Phytochemicals as
2024-02-23
Autophagy in cancer Phytochemicals as a valuable source of autophagy modulation agents Epidemiological studies demonstrated that there is a strong association between diet and human cancer mortality so that daily consumption of phytochemicals declines the incidence of different types of cancer
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Here the so called alkali assay is proposed as a
2024-02-23
Here the so-called alkali assay [18] is proposed as a method to be applied directly on the purified recombinant enzyme sharing the same structural and functional features of the wild-type enzyme [19], [20], [21] using its physiological substrate androstenedione. The assay that was already successful
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Introduction Preeclampsia a serious hypertensive disorder
2024-02-23
Introduction Preeclampsia, a serious hypertensive disorder that can occur during pregnancy, is a pregnancy-related disease characterized by the onset of pretomanid and proteinuria after the 20 t h week of gestation, and it occurs in about 5% of all pregnancies [1]. If left untreated, preeclampsia
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To date attention has been directed towards
2024-02-22
To date, attention has been directed towards new molecular targets in luminal phenotype (ER-positive), such as CDK4/6 and, to a lesser extent, androgen receptor (AR) pathways [8]. While the role of CDK4/6 has been elucidated and their inhibitors have shown a benefit in luminal BC, the role of AR in
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The current results also demonstrated tendencies toward decr
2024-02-22
The current results also demonstrated tendencies toward decreased serum Aβ40 levels and increased Aβ42 levels during the 1-year follow-up. These tendencies are consistent with the results of a previous study that evaluated Aβs in the CSF of patients with late-life depression (Pomara et al., 2016). T
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