• br Materials and methods br Results br Discussion Tuberculos

  2020-01-29

  

  Materials and methods Results Discussion Tuberculosis is caused by the mycobacterium M. tuberculosis, a pathogen able to survive in the hostile conditions through sophisticated defence mechanisms. In an attempt to clarify some aspects of the M. tuberculosis defence mechanisms, we have inves

• For a physiologically relevant interaction

  2020-01-29

  

  For a physiologically relevant interaction, ligand and receptor have to be expressed in the same place. Collagen II is found primarily in cartilage. DDR2 is expressed in proliferating chondrocytes in vivo, and its staining pattern in tibial growth plates is similar to that of collagen II. In additio

• Collagen X is a homotrimeric molecule of three X chains

  2020-01-29

  

  Collagen X is a homotrimeric molecule of three α1(X) chains (Mr 59 kDa) comprising a 45 kDa triple-helical domain flanked by an N-terminal (NC2) and a larger C-terminal (NC1) non-collagenous domains (Shen, 2005). In the hypertrophic ECM, collagen X most likely forms an extended hexagonal network, as

• br Materials and methods br Acknowledgements

  2020-01-29

  

  Materials and methods Acknowledgements SD was supported by a pre-doctoral research fellowship from the Flanders Agency for Innovation and Entrepreneurship (VLAIO-Flanders, Belgium). YB is supported by a postdoctoral fellowship from Research Foundation Flanders (FWO, Belgium). We thank Isabelle

• The intestinal cholesterol absorption markers sitosterol and

  2020-01-25

  

  The intestinal cholesterol DC_AC50 synthesis markers sitosterol and campesterol to cholesterol levels were significantly lower in Villin-Tgif1 mice compared to wild type mice, irrespective of diet. However, the decrease was less pronounced in Villin-Tgif1 mice fed a chow diet (∼20–30%) compared to

• Acidic substituents showed moderate biochemical activity but

  2020-01-25

  

  Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic Safingol were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their biochemical act

• The data presented above clearly indicate an important role

  2020-01-25

  

  The data presented above clearly indicate an important role of eIF4E for the nucleocytoplasmic transport of the human iNOS mRNA. To analyze the sequence elements of the iNOS mRNA that are important for this eIF4E-mediated transport we performed transient transfection experiments using constructs con

• One strategy which is different from the

  2020-01-25

  

  One strategy which is different from the above is to isolate a similar enzyme to the one under study which will not be recognized by the antibody of the original protein. This approach will lead to prolonging an enzyme’s activity. For example, a novel variant of Carboxypeptidase G2 (CPG2), which has

• br Methods and materials br Cyclooxygenase

  2020-01-25

  

  Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic cellular metabolism definition to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that

• With regards to what might represent a

  2020-01-25

  

  With regards to what might represent a typical “baseline” ChE (or AChE) activity in Saccostrea sp., it NCT-502 should be remembered that the observed enzyme responses were obtained in laboratory exposures, over a narrow experimental window (96h), with specimens collected over the course of a week, d

• Arsenic is an endocrine disruptor with estrogenic activity F

  2020-01-25

  

  Arsenic is an endocrine disruptor with estrogenic activity. Further study has shown that arsenic exposure can significantly increase the expression of estrogen receptor-related genes, steroid metabolism-related enzymes and lung cancer-related genes in the lung tissues of female mice on the occurrenc

• Human neutrophil elastase HNE is a serine protease central

  2020-01-25

  

  Human neutrophil elastase (HNE) is a serine protease central to the pathology in a wide range of diseases including chronic wounds, cystic fibrosis, and acute respiratory distress syndrome (Owen, 2008). Although neutrophil proteases are necessary for completion of wound healing, HNE is secreted in h

• br Chain specific ubiquitin probes The conventional way of a

  2020-01-25

  

  Chain specific ubiquitin probes The conventional way of assessing linkage specificity is by measuring turnover rates of different diubiquitin molecules as substrates. Although this method has been applied successfully in several studies [7••, 8] it is limited to isolated DUBs, whereas linkage spe

• In the gel shown in Figure at early time points

  2020-01-25

  

  In the gel shown in Figure 8, at early time-points, 14% of the input dsDNA is converted to these intermediate species. These persist in the gel to later times, with approximately 50% of these being unwound. This unwinding occurs at a considerably slower rate and is due to that fraction of the popula

• Given that CE plays an

  2020-01-25

  

  Given that CE plays an essential role in schistosome invasion, its immunoreactivity and protective potential is of significant interest. The native form of SmCE was found to be poorly immunogenic in immunized mice. An earlier study found that sera from S. mansoni patients have shown the presence of

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