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Here we describe preparation of three
2021-03-24
Here, we describe preparation of three stable conjugates that are linked by either oxyester, disulfide, or isopeptide bonds (Fig. 10.1). Each of these conjugates depends upon the prior purification of E2 and ubiquitin proteins that have been engineered to favor specific linkages. For the oxyester- a
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We propose two different pathways
2021-03-24
We propose two different pathways for the production of this species: either that described by Dooley [24], where the phenol ring is first activated by binding of its oxygen to copper, or one where a copper-peroxo species would directly react with an active site tyrosine residue (Scheme 1B). This se
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br Concluding remark br Acknowledgements br Detection and re
2021-03-24
Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human rho inhibitor daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within cancer c
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Compound was advanced to a chronic
2021-03-24
Compound 52 was advanced to a chronic efficacy study in db/db mice maintained on a high fat diet. Animals were dosed with 0.5% methylcellulose vehicle, Finasteride 52 (1, 3 or 15mg/kg, po, Q.D.) or 1 (0.3mg/kg) for 14days. Over the course of the study body weight and food intake were measured daily
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Our results suggest that formation of DDR b clusters
2021-03-24
Our results suggest that formation of DDR1b clusters may be important for and precede receptor phosphorylation. Indeed, while DDR1b clustering was readily detected (by YFP signal) 30 min after collagen administration, phosphorylated DDR1 species at Y513 (present in the IJXM) were evident after 4 h o
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The most important finding in the present study is
2021-03-24
The most important finding in the present study is that the EKR1/2-Egr-1 signaling pathway might be involve in the mechanisms underlying CysLT2 receptor-mediated IL-8 production. The signaling profile can be described by the following sequential processes: the agonists (LTC4 and LTD4) activates CysL
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The question remained as to why hCrm
2021-03-24
The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human bibf had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE complex (but
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Among the various neurotransmitter systems
2021-03-24
Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves
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ddhGTP Nociceptive and hyperalgesic actions of ET are produc
2021-03-23
Nociceptive and hyperalgesic actions of ET-1 are produced through ETA and ETB receptors. Previous reports indicate that ETA receptor antagonists in peripheral tissues are effective in inhibiting ET-1 induced hyperalgesia, and attenuation of neuropathic pain in rats [16]. Studies have also shown that
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br Acknowledgment S A was supported by V Plan
2021-03-23
Acknowledgment S.A was supported by V Plan Propio US-AccesoUSE-14793-G. Introduction Neutrophils are innate immune g proteins of primary importance for protecting against infections by microorganisms [1,2] through various antimicrobial abilities, including microorganism phagocytosis and anti
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In conclusion our study has demonstrated that PGE stimulates
2021-03-23
In conclusion, our study has demonstrated that PGE2 stimulates expression of survivin in hepatocellular carcinoma cells. Although there are 4 subtypes of EP receptors, the EP1 receptor appears to be the predominant receptor that regulates PGE2-induced expression of survivin, mainly through trans-act
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ci-1033 Anaesthetized mice of one eNOS KO
2021-03-23
Anaesthetized mice of one eNOS-KO strain showed a paradoxical decrease in blood pressure (BP) in response to i.p. administration of the NOS-inhibitor L-NA suggesting a role for non-endothelial isoforms of NOS in maintaining BP [1]. Alternatively, diminution in the activity of the renin-angiotensin s
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br Molecular characterization of LEI L DNase II LEI
2021-03-23
Molecular characterization of LEI/L-DNase II LEI, like most serpins, is a metastable protein and its anti-protease activity is related to its “stressed to relaxed transition”. So that, the inhibition of elastase by the well described suicide mechanism generates the cleaved form of LEI (see Padron
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Gene chip is a detection technique that can detect
2021-03-23
Gene chip is a detection technique that can detect all the time-point differentially expressed genes (DEGs) information within the same sample. However, due to sample heterogeneity or different sequencing platform, the results for the expressed mRNAs are inconsistent with different gene profile. The
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Regardless of its effect on EBV infection the chemokine
2021-03-23
Regardless of its effect on EBV infection, the chemokine system has been found to be regulated in both nasopharyngeal cancer and Hodgkin lymphoma. As such, Hodgkin and Reed–Sternberg (HRS) cells from Hodgkin lymphoma and nasopharyngeal carcinoma cells have been shown to express CXCL8 and CCL17. Furt
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