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br Results br Discussion The nitric oxide
2021-07-03
Results Discussion The nitric oxide-cyclic guanosine monophosphate pathway plays an important role in normal EF, and oral PDE-5Is were developed in the late 90s after the discovery that ED occurs when there is a problem with this pathway. Since then, several PDF-5Is with different pharmacokine
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The mitogen activated protein kinase MAPK
2021-07-03
The mitogen-activated protein kinase (MAPK) family, which consists of extracellular signal-regulated protein kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun N-terminal kinase (JNK), is involved in the development of NP (Hung et al., 2012, Ji et al., 2009). Recently, Zhuang et al. (2005) demonstrated that t
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Damage of PE HD due to both mechanisms
2021-07-03
Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o
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Fujimoto et al pointed out that
2021-07-03
Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC Birinapant synthesis (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irinotecan, docetaxel, doxorubi
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EphB promotes tumor growth by
2021-07-03
EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of AS-252424 and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained blood vessels
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The importance of EBI for B cell function
2021-07-03
The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed Piperine sale and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involvement of
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Cancer patients may develop cachexia a deleterious
2021-07-03
Cancer patients may develop cachexia, a deleterious wasting syndrome that is associated with muscle atrophy and has an impact on the well-being of patients and on the response to the treatment. Indeed, cachexia is a devastating and often irreversible syndrome observed in up to 80% of cancer patients
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WES and validation by Sanger sequencing in PNGS revealed an
2021-07-03
WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino HS-173 substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencing Project
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br Conflict statement br Introduction Prostate
2021-07-02
Conflict statement Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer and the second leading cause of cancer death in men after lung cancer [1], [2]. The incidence and mortality rate of prostate cancer are significantly higher in developed countries especially th
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Michel et al calculated the
2021-07-02
Michel et al. [34] calculated the mutual solubilities of water and hydrocarbons by a cubic equation of state. They asserted that conventional mixing rules can not satisfactorily describe the hydrogen bonding compounds. Kabadi and Danner [35] applied a modified form of Soave-Redlich-Kwong equation of
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The goal of this paper is
2021-07-02
The goal of this Altretamine paper is to investigate the penalized empirical likelihood method for the Cox model, as a competitor to the penalized partial likelihood. Since empirical likelihood (EL) was proposed by Owen, 1988, Owen, 2001, empirical likelihood methods have been investigated well fro
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While we are taking full
2021-07-02
While we are taking full responsibility for any remaining errors and shortcomings of the paper, we would like to thank Dr. Jong-Hyeon Jeong, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, for offering us insight and literature pointers useful in our quest to
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Introduction Enzymes have higher selectivity specificity and
2021-07-02
Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s
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br Results br Discussion br Materials and
2021-07-02
Results Discussion Materials and Methods Acknowledgment This work was funded by the Collaborative Research Centre (SFB) 807 of the German Research Foundation (DFG) and supported by the state of Hessen (Center for Biomolecular Magnetic Resonance) and the German Research Foundation (DO545/
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At first cartilage damage in
2021-07-02
At first, cartilage damage in osteoarthritis reflects the loss of proteoglycan and collagen network that increases the swelling of tissues. The incremented expression of DDR2 receptor has also co-related with the depletion of cartilage in surgically induced OA model [8]. Osteoarthritis, a degenerati
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