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br Introduction The cys loop ligand gated
2021-07-29
Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri
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In the present study cells
2021-07-29
In the present study, cells were exposed to a low level of arsenite and a low cytotoxic concentration of BaP. Thus, γ-H2AX loss correlated with repair of DNA damage in cells co-exposed to arsenite and BaP. These results show that arsenite inhibits repair of BaP-induced DNA damage. In a previous stud
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Thus the understanding of the various mechanisms
2021-07-29
Thus, the understanding of the various mechanisms of action of estrogen and SERMs is an important medical challenge and could help to develop an “ideal” SERM, preserving the beneficial effects of estrogen in the bone and urogenital system, and reducing the unwanted side effects, mainly increased ris
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ATP binding cassette transporters such as ABCA and ABCG are
2021-07-29
ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from (R,S)-Anatabine to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation of liver X rece
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KP372-1 It is very important to
2021-07-29
It is very important to decide what the best time of NIR laser irradiation is for the optimized PTT. So the best way is to monitor the biodistribution of the nanoparticles in various tissues (specially, in tumors) temporally and spatially after iv injection. Based on the combined functions of therap
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Upon assembly of HLA tetramers loaded
2021-07-29
Upon assembly of HLA tetramers loaded with either of the two peptide versions, we could query the T cell repertoires of RA subjects and healthy individuals for the presence of cognate T Fidaxomicin recognizing the respective peptide-HLA complexes. We found no significant difference in frequencies o
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A cocktail approach can detect the activities of multiple
2021-07-29
A cocktail approach can detect the activities of multiple CYP 450 isoforms following administration of multiple CYP-specific substrates in a single experiment. Caffeine, losartan, omeprazole, dextromethorphan and midazolam are often used as substrates in “cocktail probes” of human cytochrome CYP1A2,
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HOIP s ability to build
2021-07-29
HOIP's ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [40
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TNF-alpha, recombinant murine protein br Materials and Metho
2021-07-29
Materials and Methods Acknowledgements Authors would like to thank Mr. Pritam Naskar and Mr. Dibya Mukherjee for their help. Authors also acknowledge the help of Mr. Barun Mahata and Dr. Kaushik Biswas, Division of Molecular Medicine, Bose Institute, for human cDNA samples. P.A.B. and A.B.D. w
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We found that the postnatal absence
2021-07-29
We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and factor xa region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocampus in Dbh−/−
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Compound was advanced to a chronic
2021-07-29
Compound 52 was advanced to a chronic efficacy study in db/db mice maintained on a high fat diet. Animals were dosed with 0.5% methylcellulose vehicle, tak1 inhibitor 52 (1, 3 or 15mg/kg, po, Q.D.) or 1 (0.3mg/kg) for 14days. Over the course of the study body weight and food intake were measured da
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By stratifying EOC cell lines according
2021-07-29
By stratifying EOC cell lines according to their EMT stages, we observed a significant higher expression of DDR1 in the epithelial-like cell lines compared to low or undetectable DDR1 in mesenchymal-like cell lines. Similar trend was observed in the tumour samples, with the lowest expression of DDR1
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br Introduction Alzheimer s disease AD
2021-07-29
Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the MK-2461 nerves cells, or neurons, resulting in loss of memory, impairment of thinking a
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br CDK Inhibitors for the Treatment of inflammatory Diseases
2021-07-29
CDK Inhibitors for the Treatment of inflammatory Diseases Several CDKs have been implicated as regulators of inflammatory gene expression. It will thus be very important to determine the relative contributions of the various CDKs and their kinase function on a systematic basis. This work will be
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br Materials and methods br Results and discussion br
2021-07-29
Materials and methods Results and discussion Acknowledgements This study was supported by the Open Project Program of the Key Laboratory of Mariculture & Enhancement of Zhejiang Province (No. 2016KF003), the Key Project of Zhejiang Province (No. 2016C02055-7), and the International Science
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