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The differences between ground and transition state properti
2021-08-06
The differences between ground and transition state properties are exemplified by a comparison of our human–yeast results with those of a structural study of possible differences in ubiquitin-Uba-1 binding in yeast (known structure) with human (simulated in [12]). Their discussion focuses on Ubiquit
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br Acknowledgements This work was supported by National Natu
2021-08-06
Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241). Introduction Fluoride, as a member of the halogen group of elements, naturally existed in water, soil, animals, and plants around the world (Singh et al., 2018), and it is present in trace
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Another mechanism underlying on the toxicity of dopaminergic
2021-08-06
Another mechanism underlying on the toxicity of dopaminergic neurons might be related to dopamine-dependent initial oxidative stress [60]. Dopamine BMS345541 hydrochloride mediated by monoamine oxidase (MAO) can produce hydrogen peroxide as a by-product, and excess dopamine can undergo auto-oxidati
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br Introduction Acinetobacter baumannii is a gram negative o
2021-08-06
Introduction Acinetobacter baumannii is a gram-negative opportunistic pathogen that causes nosocomial infections including pneumonia and bloodstream infections which is associated with an increased mortality and multi-drug resistance [[1], [2], [3]]. A. baumannii was rated as one of the critical
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Regarding their reported beneficial properties on the
2021-08-06
Regarding their reported beneficial properties on the digestive tract, the aim of this study was to evaluate the effect of water extracts of three Hypericum sps., HP, HA, HU and some of the main phenolic compounds (Ch, R and Q) on DNA protection against oxidative and alkylating DNA damage induced by
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br Discussion Electroporation is a convenient and efficient
2021-08-06
Discussion Electroporation is a convenient and efficient way to introduce foreign material into Lck Inhibitor [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevant to successful ele
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br Conflicts of interest br Introduction Arylamine N acetylt
2021-08-06
Conflicts of interest Introduction Arylamine N-acetyltransferase 1 (NAT1, EC 2.3.1.5) is a cytosolic enzyme that catalyses the acetylation of small molecule arylamines, hydrazines and sulphonamides (Hein, 2002). Found in most MPTP hydrochloride in the body, NAT1 expression is regulated at the
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br Methods br Results br Discussion
2021-08-06
Methods Results Discussion MEN91507 is a potent and selective CysLT1 receptor antagonist. Guinea-pig lung membranes have been widely used for the detection and characterization of CysLT1 receptor antagonists: in this assay the high affinity (subnanomolar) binding of [3H[leukotriene D4 or [3
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Diclofenac ibuprofen and meloxicam are considered among the
2021-08-06
Diclofenac, ibuprofen, and meloxicam are considered among the most commonly used NSAIDs in many countries [4]. Cardiovascular events were reported with these NSAIDs in several clinical studies. In this study, we provide novel information that diclofenac and ibuprofen altered gene expression and may
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The genomic DNA sequences of CXCL and CXCRs
2021-08-06
The genomic DNA sequences of CXCL8 and CXCRs were retrieved from the fugu genome database v4.0. The intron–exon boundaries were identified with the corresponding cDNA sequences. This comparison revealed that the fugu gene is about 1.13kb long and contains four exons separated by three introns (top
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br Nuclear export and the functions of
2021-08-06
Nuclear export and the functions of CRM1 The nuclear envelope provides a compartmentalized intracellular environment for DNA replication, the synthesis of RNA, and production of ribosomes, and, as such, it can regulate cellular biological processes including apoptosis and proliferation. Nucleocyt
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ProteOrange Besides the regulation of the stress responses C
2021-08-06
Besides the regulation of the stress responses, CRF and the urocortins have been implicated in drug addiction (Bruijnzeel and Gold, 2005, Sarnyai et al., 2001). For instance nicotine, the addictive substance of tobacco, can activate the HPA axis, just like any other stressor may do, although its imp
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The serotonin transporter gene encodes an integral membrane
2021-08-05
The serotonin transporter gene () encodes an integral membrane protein that transports serotonin from the synaptic spaces into the presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent way. This protein is a target of psychomotor stimulants
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Phenylbenzofurans are a very important molecule skeleton due
2021-08-05
Phenylbenzofurans are a very important molecule skeleton due to their synthetic versatility and their proved pharmacological properties [2]. They are synthetic compounds in which an additional phenyl ring is present in any position of the benzofuran nucleus. This could be easily obtained possible by
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br Conflict of interest br
2021-08-05
Conflict of interest Acknowledgements This study was supported by the National Natural Science Foundation of China (No.31571839), the Chinese Ministry Program for New Century Excellent Talents in University (NCET-12-0865), and Special Fund for Agro-scientific Research in the Public Interest (N
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