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In a study performed simultaneously
2020-01-10
In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived 5 alpha reductase resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarc
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br Material and methods br Results br Discussion A fumigatus
2020-01-10
Material and methods Results Discussion A. fumigatus utilizes several virulence factors that facilitate its establishment in human hosts. Among these factors, the best known are hydrolytic enzymes such as proteases and phospholipases, toxins, melanine and catalases that neutralize the react
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In conclusion we demonstrate that infection of
2020-01-10
In conclusion we demonstrate that infection of salmon cells with ISAV induce the main branches of the cellular UPR machinery, but also one of its main negative regulators, GADD34. This is probably important for maintaining translation of interferon and interferon stimulated genes (ISGs), keeping ISA
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CD is a key co stimulation
2020-01-09
CD28 is a key co-stimulation surface marker that can be detected in all peripheral T Y-27632 synthesis in newborns, and the proportion of CD28bearing T cells reduces progressively with age [reviewed by (Fagnoni et al., 1996; Weng et al., 2009)]. Therefore, CD28nullCD8+ T cells are one of the most a
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The mechanisms by which Cav enhances embryonal
2020-01-09
The mechanisms by which Cav-1 enhances embryonal tumor progression are currently unknown. Given the documented ability of Cav-1 to drive increased biogenesis of caveolae and accelerate the flow of nutrients (mostly glucose and fatty acids) across the membrane, as observed in particular in adipocytes
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In addition to through direct regulation of cell differentia
2020-01-09
In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the
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Various domains of DDR have
2020-01-09
Various domains of DDR1 have been shown to be important for receptor clustering and its oligomeric status. It is now understood that (i) dimerization [7] and higher-order oligomerization [12], [18] of the DDR1 extracellular domain (ECD) enhance its binding to collagen; (ii) DDR1 exists as non-covale
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Introduction Quassinoids are natural products formed through
2020-01-09
Introduction Quassinoids are natural products formed through the oxidative degradation of triterpene derivatives with anti-inflammatory, antimicrobial, antineoplastic, and antiplasmodial effects (Chakraborty and Pal, 2013; Houël et al., 2013). They are characteristic ingredients of the family Simar
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RU 58668 Where a a a and b
2020-01-09
Where a, a, a and b, b, b are respectively, repulsive friction constants and attraction friction constants. c represents the quadratic repulsive friction constant and P is critical pressure (bar). CPA equation of state CPA model is an EOS that simply combines a cubic EOS (SRK-EOS) and an assoc
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In the case of high fidelity polymerases we propose that
2020-01-09
In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this
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SB203580 Finally this study described that
2020-01-09
Finally, this study described that the lead SB203580 (1) acted as an efficient alkylating agent for the G4 structure in addition to the previously reported T-T mismatch structure. The shortcoming of probe (1) is the lack of a structure selectivity, but that can be overcome by changing the acridine
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br Steroid biosynthesis br Steroid hormone metabolism in bre
2020-01-09
Steroid biosynthesis Steroid hormone metabolism in breast cancer Conclusion Steroid hormones elicit their biological actions primarily by binding to steroid receptors such as the ER, AR, PR and GR. Although classical breast cancer diagnostic panels assess the expression of the ER and PR, as
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back off Behaviors were compared between saline and amphetam
2020-01-08
Behaviors were compared between saline and amphetamine pre-treatment groups at 24h and 2 weeks following the last treatment, or between pre-treatment groups that received vehicle or ASV-30 infusions, using separate two-way ANOVAs. Significant effects were analyzed further using Student–Newman–Keuls
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br Results br Discussion In this paper we
2020-01-08
Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 AZ505 ditrifluoroacetate via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the select
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Endothelin appears to have direct
2020-01-08
Endothelin 1 appears to have direct effects on neoplastic Cap Firefly Luciferase mRNA by inducing cellular proliferation, angiogenesis, migration, invasion, and inhibition of apoptosis [10]. Endothelin 1 mediates mitogenic effects in some epithelial tumors such as colorectal, ovarian, and prostate
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