• If the lack of specificity and the

  2025-02-26

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Pertussis Toxin may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as l

• The most likely explanation for

  2025-02-26

  

  The most likely explanation for the species differences in aromatase distribution and the unique guanidine hydrochloride distribution in humans is the unique location, size and highly elaborate organization of the human aromatase gene (e.g. Bulun et al., 2003). The human Cyp19 is a large gene locat

• br Conflicts of interest br Contributors br Introduction Lip

  2025-02-25

  

  Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti

• Introduction Heterotrimeric G proteins mediate signal transd

  2025-02-25

  

  Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s

• 96 7 br Experimental section br Acknowledgment S B T is

  2025-02-25

  

  Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont

• Bioinformatics tools are becoming more powerful and reliable

  2025-02-25

  

  Bioinformatics tools are becoming more powerful and reliable due to the growing number and availability of experimentally determined protein structures (Arnold et al., 2006, Suplatov et al., 2015, Wiltgen and Tilz, 2009). The SWISS-MODEL and MODELLER programs are most frequently used for homology or

• br Conclusions br Introduction During numerous

  2025-02-25

  

  Conclusions Introduction During numerous physiological processes, aldehydes are generated from a variety of endogenous and exogenous precursors including amino acids, carbohydrates, and lipids [1]. Most aldehydes are highly reactive and cytotoxic due to the strong electrophilic nature of the t

• Taken together our results indicated

  2025-02-25

  

  Taken together, our results indicated that 5-LOX can be induced in mice by MPTP injection, and the 5-LOX inhibitor MK-886 reduced the death of dopaminergic neurons. MK-886 also reduced the LTB4 5ar inhibitors induced by MPTP. The development of the novel 5-LOX or FLAP inhibitors may provide a new th

• Laminin 925-933 br Role of LPA in tumor angiogenesis

  2025-02-25

  

  Role of LPA in tumor angiogenesis and skeletal metastasis The angiogenesis switch is essential for tumor expansion and escape of tumor Laminin 925-933 from the primary site and forming distant metastases. Evidence for the role of LPA2 and LPA3 in the mobility of endothelial cells and the formati

• Ryoichi et al modified potent clinical candidate VX with cya

  2025-02-24

  

  Ryoichi et al. modified potent clinical candidate VX-680 (6) with 3-cyano-6-(5-methyl-3-pyrazolamino)pyridine as Aurora kinase inhibitor. Substituted cyano pyridine derivative (7) inhibited proliferation of HCT-116 cells with an IC50 value of 115 nM. It showed tumor inhibition in mice model at a dos

• The analysis of the profile of protein phosphorylation

  2025-02-24

  

  The analysis of the profile of protein phosphorylation in MMS-treated dpni confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst in the absence of

• br Ataxia telangiectasia and Rad related as

  2025-02-24

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• For the TSH receptor signaling at the Golgi trans Golgi

  2025-02-24

  

  For the TSH receptor, signaling at the Golgi/trans-Golgi network appears required for both rapid effects of TSH − such as NP118809 depolymerization, which is implicated in thyroglobulin reuptake and, thus, thyroid hormone release − and late ones, such as those on gene transcription. Continued signa

• SLIGKV-NH2 A different mechanism has been suggested for the

  2025-02-24

  

  A different mechanism has been suggested for the role of TRX1 in ASK1 regulation based on disulfide bond-mediated ASK1 multimerization and its reduction through the thiol-reductase activity of TRX1 (Nadeau et al., 2007, Nadeau et al., 2009). In this model, oxidative stress induces intermolecular dis

• Recently rather than predicting categorical variables as

  2025-02-24

  

  Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from GSK2334470 images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regression focus

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