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  • Click chemistry is a kind of chemical synthesis to

    2020-08-03

    Click chemistry is a kind of chemical synthesis to acquire various molecular product through small units quickly assembling. It has been applied to natural polymers or synthetic origins in many different architectures including linear (e.g., PEG, polysaccharides, proteins), branched (e.g., dendrimers, graft polymers) and macrocyclic polymers [46]. Oxime click chemistry [47] has been used to crosslink hydrogels of poly(ethylene glycol)s (PEGs), HA and collagen [48] that were biodegradable, soft, and supportive of cell adhesion. Furthermore, collagen could be further utilized to surface modification of biologically inert materials, such as Imatinib australia materials and metal materials, which are always hydrophobic, lacking functional groups and poor cell adhesion. Therefore, various strategies have been tested to improve the properties of these materials including plasma deposition processes, surface immobilization of biopolymers (e.g. gelatin, chitosan, collagen), attachment of bioactive peptides (RGD peptide) and surface mineralization [49,50]. The group of InĂªs Sousa modified PCL scaffold with plasma treatment, then acrylic acid grafting and collagen immobilization to improve the hydrophily and cell adhesion of PCL [51]. The bio-function dendrimer is shown in Fig. 7 [52].
    Recent biomedical applications of collagen based materials
    Conclusion and future prospects
    Acknowledgements This work is supported by National Natural Science Foundation of China (21808133, 21804084), Scientific Research Foundation for Young Scholars (contract grant number 2017BT-32), Shaanxi University of Science & Technology, Shaanxi Province Key R&D Program (2018ZDXM-SF-091).